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10.1002/14651858.CD004655.pub3 [DOI] [PMC free article] [PubMed] 10.Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)

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Most people notice improved energy within a few days to a few weeks, depending on how low their levels are and how their body responds to treatment